Model-Based Comparison of Antibody Dimerization in Continuous and Batch-Wise Downstream Processing

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Model-Based Comparison of Antibody Dimerization in Continuous and Batch-Wise Downstream Processing

Monoclonal antibodies are generally produced using a generic platform approach in which several chromatographic separations assure high purity of the product. Dimerization can occur during the fermentation stage and may occur also during the downstream processing. We present here simulations in which a traditional platform approach that consist of protein A capture, followed by cation-exchange ...

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ژورنال

عنوان ژورنال: Antibodies

سال: 2015

ISSN: 2073-4468

DOI: 10.3390/antib4030157